Optimized for the Cryo-EM Autoloader Workflow

Our AutoGrid rings are engineered to strict tolerances to ensure smooth handling by the Cryo-EM autoloader robots found in Titan Krios, Glacios, and Talos AutoGrid systems. The precise AutoGrid ring geometry prevents jamming during AutoGrid cassette loading and ensures perfect seating in the stage.

Designed for the rigorous AutoGrid clipping process, these rings pair perfectly with our resilient C-clip rings (circlips), maintaining grid flatness and stability even when performing grid clipping under LN2 (liquid nitrogen).

Solutions for Cryo-FIB and Tomography

We offer specialized rings for the FIB-SEM AutoGrid workflow. These FIB AutoGrid rings feature a specific cutout geometry that provides access for low-angle ion beams, essential for FIB lamella milling on the Aquilos FIB. This design maximizes the accessible AutoGrid milling area without compromising mechanical stability during cryo-FIB grid preparation.

Cost-Effective Quality & Compatibility

As a cost-effective AutoGrid alternative, our TFS compatible rings offer the same reliability as OEM parts. They function seamlessly with standard AutoGrid clipping stations and AutoGrid clipping tools. Each batch undergoes rigorous AutoGrid quality control to ensure uniformity in thickness and diameter.

Product Type	Application	Compatibility
Standard AutoGrid Ring	Single Particle Analysis (SPA)	Krios, Glacios, Talos, Arctica
FIB AutoGrid Ring	Cryo-FIB / Tomography	Aquilos, Scios, Helios (FIB-SEM)
AutoGrid C-Clip	Securing Grid in Ring	All AutoGrid Rings

Frequently Asked Questions

1. Are these rings compatible with the Thermo Fisher (FEI) Clipping Station?

Yes. Our rings and C-clips are manufactured to identical specifications as TFS compatible rings, ensuring they fit perfectly into the standard AutoGrid clipping station and work with standard AutoGrid tweezers.

2. What is the difference between Standard and FIB rings?

Standard AutoGrid rings are continuous and used for most imaging. FIB AutoGrid rings have a "D" shape or cutout that allows the ion beam to mill the grid at shallow angles without shadowing, critical for FIB lamella milling.

3. Can these be reused?

While possible, de-clipping AutoGrids can deform the C-clip. It is generally recommended to use new C-clips for each sample to ensure secure retention, though the AutoGrid rings themselves can often be cleaned and reused if not damaged.

4. Do the rings have orientation marks?

Yes, our rings feature standard AutoGrid orientation marks (a small notch or flat) to help align the grid axis relative to the tilt axis of the microscope, which is vital for Cryo-ET AutoGrid workflows.

5. How do I ensure the C-clip is seated correctly?

During AutoGrid inspection, check for "C-clip bottoming"—the clip should be fully seated in the groove. Using a clipping tool rack with good lighting helps verify this before loading into the cassette.