UltrAuFoil® Holey Gold Support Films are state-of-the-art Cryo-EM grids designed for ultrahigh-resolution electron microscopy. Featuring precisely patterned nanometer-scale holes on ultrastable gold substrates, these grids provide unparalleled mechanical stability, reduced beam-induced motion, and optimized sample support for single-particle analysis, cryo-electron tomography (Cryo-ET), and structural biology research.
Unlike traditional carbon-based TEM supports, UltrAuFoil® gold grids offer enhanced conductivity, lower charging effects, and superior thermal stability, making them ideal for demanding Cryo-EM applications that require pristine imaging quality.
These grids are extensively used in structural biology, pharmaceutical research, and nanotechnology, ensuring consistent, reproducible, and high-contrast imaging for molecular and macromolecular analysis.
1. High-Stability Holey Gold Film for Cryo-EM
- Ultrathin gold support provides exceptional mechanical stability and conductivity.
- Minimizes beam-induced motion, leading to higher-resolution Cryo-EM imaging.
- Low background noise enhances contrast and improves Cryo-EM data collection.
2. Optimized for Single-Particle Analysis & Cryo-ET
- Nanopatterned holey gold structure supports optimal ice thickness for vitrified samples.
- Superior electron transparency enables detailed molecular structure visualization.
- Ideal for challenging biomolecules, including membrane proteins and macromolecular complexes.
3. Enhanced Imaging Performance & Data Quality
- Prevents charging effects for consistent and reproducible Cryo-EM imaging.
- Gold foil design ensures reliable heat dissipation and sample stability.
- Designed for automated Cryo-EM workflows, improving high-throughput data collection.
4. Versatile Applications in Advanced Electron Microscopy
- Compatible with a range of Cryo-EM systems and transmission electron microscopes.
- Used in structural biology, nanotechnology, and drug discovery research.
- Facilitates improved image alignment for Cryo-EM reconstruction.
| Feature | Specification |
|---|---|
| Material | Ultrathin Gold Film |
| Grid Type | Holey Gold TEM Grid |
| Hole Diameter | 1.2 μm – 2.0 μm |
| Grid Mesh Size | 200 - 400 Mesh |
| Thickness | 10 nm – 50 nm |
| Electron Transparency | High |
| Beam Stability | Low Motion, High Conductivity |
| Surface Properties | Low-Charging, Conductive |
| Applications | Cryo-EM, Structural Biology, Nanotechnology |
1. Cryo-Electron Microscopy (Cryo-EM) for Structural Biology
- Enables high-resolution imaging of proteins, viruses, and macromolecular complexes.
- Enhances contrast and stability for single-particle analysis and Cryo-ET.
- Used in drug discovery and protein-ligand interaction studies.
2. High-Resolution Transmission Electron Microscopy (TEM)
- Optimized for electron diffraction and structural characterization.
- Reduces beam-induced motion, improving resolution in Cryo-EM data collection.
- Ideal for imaging biological macromolecules and soft materials.
3. Nanotechnology & Material Science Applications
- Supports analysis of nanoparticles, polymers, and ultrathin films.
- Enhances imaging of 2D materials, including graphene and semiconductors.
- Essential for the study of nanomaterials under low-dose electron exposure.
- Ultra-Stable Gold Support – Provides maximum mechanical stability and reduced drift.
- Superior Beam-Induced Motion Reduction – Improves Cryo-EM data quality and resolution.
- Low Background & High Contrast Imaging – Enhances signal-to-noise ratio for better visualization.
- Optimal Sample Support – Ensures consistent ice thickness for vitrified Cryo-EM samples.
- Automated Workflow Compatibility – Designed for high-throughput Cryo-EM and tomography studies.
- Reduced Charging Effects – Enhances electron dose efficiency and data reproducibility.
- Proven Performance in Structural Biology – Trusted by leading Cryo-EM laboratories worldwide.
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