Quantifoil® TEM grids are specialized electron microscopy substrates designed for Cryo-EM (Cryogenic Electron Microscopy) and high-resolution Transmission Electron Microscopy (TEM) applications. These grids provide a stable and uniform support structure for biological macromolecules, nanoparticles, and material science research.
Featuring holey carbon films, ultrathin carbon supports, and gold-supported UltrAuFoil® grids, Quantifoil® substrates ensure minimal background noise, enhanced contrast, and optimal sample retention for superior imaging in single-particle analysis, cryo-electron tomography (cryo-ET), and high-resolution TEM studies.
Engineered for consistent hole size and distribution, these grids enhance data collection efficiency, facilitate sample preparation, and improve overall imaging quality, making them the gold standard in Cryo-EM and TEM research.
1. High-Precision Holey Carbon & Gold Support Films
- Uniform hole patterns provide consistent sample distribution for high-resolution imaging.
- Available in different hole sizes to optimize contrast and signal-to-noise ratio.
- Gold-supported UltrAuFoil® grids improve mechanical stability and conductivity.
2. Ideal for Cryo-EM Sample Preparation & TEM Studies
- Supports vitrified samples for single-particle Cryo-EM and cryo-electron tomography.
- Ultrathin carbon films ensure minimal electron scattering and better sample contrast.
- Graphene TEM grids reduce charging effects and provide enhanced sample stability.
3. Advanced Surface Chemistry & Grid Stability
- Low-background carbon supports minimize interference for accurate Cryo-EM data collection.
- Active grid technology enhances sample adherence while reducing contamination risks.
- Pre-treated surfaces available for improved sample retention and spreading.
4. Optimized for High-Resolution TEM Imaging
- Electron-transparent substrates ensure better imaging of biological macromolecules.
- Strong structural integrity prevents grid damage during freezing and handling.
- Compatible with automated Cryo-EM workflows for high-throughput data collection.
| Feature | Specification |
|---|---|
| Grid Material | Holey Carbon, UltrAuFoil® Gold, Graphene |
| Hole Diameter | 1.2 μm – 2.0 μm |
| Grid Size | 200 - 400 Mesh |
| Support Film Thickness | ~10 nm – 50 nm |
| Surface Chemistry | Standard & Pre-Treated Options Available |
| Sample Compatibility | Biological Macromolecules, Nanoparticles, Polymers |
| Applications | Cryo-EM, Electron Microscopy, Material Sciences |
1. Cryo-Electron Microscopy (Cryo-EM)
- Single-particle analysis for protein structure determination.
- Cryo-electron tomography (cryo-ET) for 3D visualization of macromolecules.
- Structural biology research for drug discovery and molecular modeling.
2. Transmission Electron Microscopy (TEM)
- Nanoparticle and material characterization in nanotechnology.
- Electron diffraction studies for crystalline structure analysis.
- Thin-section electron microscopy in biomedical and material sciences.
3. Electron Microscopy in Life Sciences & Material Research
- Supports imaging of viruses, ribosomes, and cell organelles.
- Used in semiconductor and polymer research.
- Enhances resolution in electron energy loss spectroscopy (EELS) studies.
- Optimized for Cryo-EM & TEM Studies – Ensures high-resolution imaging and accurate sample retention.
- Holey Carbon & Gold Support Films – Provides uniform support for biological and material samples.
- Ultra-Low Background Noise – Minimizes interference, enhancing contrast in electron microscopy.
- Compatible with Automated Data Collection – Ideal for high-throughput Cryo-EM workflows.
- Strong Mechanical Stability – Resistant to grid warping, ensuring reproducible results.
- Pre-Treated Surfaces Available – Enhances sample adherence while reducing contamination risks.
